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Invitrogen

DKK1 Recombinant Rabbit Monoclonal Antibody (R015)

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DKK1 Recombinant Rabbit Monoclonal Antibody (R015)

Product Details

MA5-43084

Applications
Tested Dilution
Publications

Neutralization (Neu)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

R015

Immunogen

Recombinant Human DKK-1 protein (2-266).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A

Storage buffer

arginine/histidine with 0.02% Tween 80, 120mM NaCl

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912224

Product Specific Information

Specificity: Human DKK-1

Target Information

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dickkopf 1 homolog; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; hDkk1; secreted wnt inhibitor with affinity for heparin sepharose; SK; unnamed protein product

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Gene Aliases: DKK-1; DKK1; SK; UNQ492/PRO1008

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UniProt ID: (Human) O94907

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Entrez Gene ID: (Human) 22943

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Function(s)
protein binding growth factor activity co-receptor binding receptor antagonist activity low-density lipoprotein particle receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis endoderm formation mesoderm formation hair follicle development regulation of receptor internalization heart induction heart valve development endocardial cushion development endoderm development learning or memory positive regulation of gene expression negative regulation of neuron projection development Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of Wnt signaling pathway negative regulation of ossification embryonic limb morphogenesis negative regulation of BMP signaling pathway forebrain development response to retinoic acid negative regulation of mesodermal cell fate specification regulation of endodermal cell fate specification negative regulation of apoptotic process regulation of neuron apoptotic process positive regulation of Wnt signaling pathway, calcium modulating pathway positive regulation of JNK cascade regulation of synapse organization regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway limb development head morphogenesis face morphogenesis negative regulation of SMAD protein import into nucleus motor learning negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis synapse pruning regulation of dopaminergic neuron differentiation negative regulation of Wnt-Frizzled-LRP5/6 complex assembly positive regulation of midbrain dopaminergic neuron differentiation negative regulation of presynapse assembly positive regulation of Wnt signaling pathway, planar cell polarity pathway negative regulation of cardiac muscle cell differentiation
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