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Antibody detects endogenous levels of total DKK2.
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dickkopf 2; dickkopf 2 homolog; Dickkopf gene 2; dickkopf homolog 1; dickkopf homolog 2; dickkopf homolog 4; dickkopf related protein-2; Dickkopf-2; Dickkopf-related protein 2; dkk-2; hDkk-2; mDkk-2
Gene Aliases: DKK-2; DKK2; Dkk4; UNQ682/PRO1316
UniProt ID: (Human) Q9UBU2, (Mouse) Q9QYZ8
Entrez Gene ID: (Human) 27123, (Mouse) 56811, (Rat) 295445
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