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Invitrogen
DLD Polyclonal Antibody
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FIGURE: 1 / 4
DLD Antibody (PA5-92447) in IHC (P)
Immunohistochemistry analysis of DLD in paraffin-embedded human colon carcinoma. Samples were incubated with DLD Polyclonal antibody (Product # PA5-92447) using a dilution of 1:500 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-92447
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 36-300 of human DLDH/DLDH/DLDH/DLD (NP_0000992)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
28 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ADQPIDADVT VIGSGPGGYV AAIKAAQLGF KTVCIEKNET LGGTCLNVGC IPSKALLNNS HYYHMAHGKD FASRGIEMSE VRLNLDKMME QKSTAVKALT GGIAHLFKQN KVVHVNGYGK ITGKNQVTAT KADGGTQVID TKNILIATGS EVTPFPGITI DEDTIVSSTG ALSLKKVPEK MVVIGAGVIG VELGSVWQRL GADVTAVEFL GHVGGVGIDM EISKNFQRIL QKQGFKFKLN TKVTGATKKS DGKIDVSIEA ASGGK; Positive Samples: MCF7, BT-474, K-562, 293T, Mouse kidney, Mouse skeletal muscle, Mouse liver; Cellular Location: Mitochondrion matrix
Target Information
This gene encodes the L protein of the mitochondrial glycine cleavage system. The L protein, also named dihydrolipoamide dehydrogenase, is also a component of the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex, and the branched-chain alpha-keto acide dehydrogenase complex. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: branched chain alpha-keto acid dehydrogenase complex subunit E3; diaphorase; Dihydrolipoamide dehydrogenase; dihydrolipoamide dehydrogenase precursor; Dihydrolipoyl dehydrogenase, mitochondrial; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; epididymis secretory sperm binding protein; Glycine cleavage system L protein; glycine cleavage system protein L; lipoamide dehydrogenase; lipoamide dehydrogenase precursor old gene name 'LAD'; lipoamide reductase; lipoyl dehydrogenase; OTTHUMP00000206744; OTTHUMP00000206746; OTTHUMP00000206748; OTTHUMP00000206749; PH; PHE 3; pyruvate dehydrogenase complex subunit E3, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex, glycine cleavage system protein L; unnamed protein product
Gene Aliases: DLD; DLDD; DLDH; E3; GCSL; LAD; OGDC-E3; PHE3
UniProt ID: (Human) P09622, (Mouse) O08749
Entrez Gene ID: (Human) 1738, (Mouse) 13382
acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
2-oxoglutarate metabolic process
mitochondrial electron transport, NADH to ubiquinone
proteolysis
gastrulation
branched-chain amino acid catabolic process
regulation of membrane potential
sperm capacitation
2-oxoglutarate decarboxylation to succinyl-CoA
branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
lipoate metabolic process
cell redox homeostasis
dihydrolipoamide metabolic process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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