Proteintech

DLG1 Polyclonal Antibody

View all (11) SAP97 antibodies

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DLG1 Antibody in Western Blot (WB) — Mouse lung tissue were subjected to SDS PAGE followed by western blot with 55085-1-AP (DLG1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

DLG1 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 55085-1-AP (DLG1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

Applications

Tested Dilution

Publications

Immunofluorescence (IF)

Assay-dependent

View 1 publication 1 publication

Western Blot (WB)

1:200-1:1000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

The antibody is specific to DLG1.

Target Information

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; Disks large homolog 1; DKFZp761P0818; DKFZp781B0426; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97

Gene Aliases: B130052P05Rik; dJ1061C18.1.1; DLG1; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q811D0

Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

Molecular Function: transmembrane receptor regulatory/adaptor protein

negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye T cell cytokine production protein dephosphorylation actin filament organization mitotic cell cycle checkpoint establishment or maintenance of cell polarity chemical synaptic transmission nervous system development positive regulation of cell proliferation regulation of cell shape viral process single organismal cell-cell adhesion peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization astral microtubule organization membrane raft organization regulation of myelination activation of protein kinase activity ion transmembrane transport cellular protein complex localization T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering positive regulation of potassium ion transport cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle GMP metabolic process GDP metabolic process reproductive structure development embryonic skeletal system morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation establishment of centrosome localization negative regulation of protein kinase B signaling hard palate development negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane receptor localization to synapse regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport negative regulation of p38MAPK cascade ureteric bud development cell adhesion protein localization regulation of protein localization nucleotide phosphorylation tissue morphogenesis positive regulation of multicellular organism growth positive regulation of developmental growth

Process(es)

guanylate kinase activity phosphoprotein phosphatase activity protein binding protein C-terminus binding cytoskeletal protein binding ligand-gated ion channel activity potassium channel regulator activity protein kinase binding phosphatase binding mitogen-activated protein kinase kinase binding protein complex scaffold ionotropic glutamate receptor binding ion channel binding L27 domain binding cadherin binding involved in cell-cell adhesion PDZ domain binding kinase binding