|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide made specifically to the human BP1 protein sequence (residues 1-60). There is no homology to DLX4 or DLX7.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
The target sequence has 82% sequence homology with mouse.
DLX (Distal-less) genes are essential for early development. BP1 (beta protein 1) is a homeodomain-containing isoform of DLX4. Strong BP1 expression is seen in placenta and kidney tissue, with no expression found in any other tissue. This protein has been shown to be activated in 80% of invasive ductal breast tumors and is associated with breast cancer progression. It is also expressed in the bone marrows of 63% of acute myeloid leukemia (AML) patients. In addition, BP1 plays a role in globin gene regulation by repressing the beta- globin gene .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta protein 1; Beta protein 1 BP1; distal-less homeo box 7; distal-less homeo box 9; Distal-less homeobox 4 (isoform a); Distal-less homeobox 7; DLX4; DLX7; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8
Gene Aliases: BP1; DLX4; DLX7; DLX8; DLX9; OFC15
UniProt ID: (Human) Q92988
Entrez Gene ID: (Human) 1748
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