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Invitrogen
DMAP1 Polyclonal Antibody
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FIGURE: 1 / 1
DMAP1 Antibody (PA5149575) in ChIP
ChIP Assay of DMAP1 in K562 cells. ChIP-Exo-Seq composite graph for DMAP1 polyclonal antibody (Product # PA5149575). Strand-specific reads (blue: forward, red: reverse) and IgG controls (black: forward, grey: reverse) are plotted against the distance from a composite set of reference binding sites. The antibody exhibits robust target enrichment compared to a non-specific IgG control and precisely reveals its structural organization around the binding site.
Product Details
PA5149575
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DMAP1
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AEEEYLLQEL RKIEARKKER EKRSQDLQKL ITAADTTAEQ RRTERKAPKK KLPQKKEAEK PAVPETAGIK FPDFKSAGVT LRSQRMKLPS SVGQKKI
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. DMAP1 is found in a wide variety of living organisms from yeasts to humans. The human DMAP1 gene is localized on chromosome 1p34.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686L09142; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein 1; FLJ11543; RP5-891H21.2; unnamed protein product
Gene Aliases: DMAP1; DNMAP1; DNMTAP1; EAF2; KIAA1425; MEAF2; SWC4
UniProt ID: (Human) Q9NPF5
Entrez Gene ID: (Human) 55929
negative regulation of transcription from RNA polymerase II promoter
DNA repair
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
positive regulation of protein import into nucleus
regulation of apoptotic process
response to ethanol
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of cell cycle
positive regulation of double-strand break repair via homologous recombination
regulation of double-strand break repair
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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