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|Tested species reactivity||Mouse|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from the C-terminal region of the mouse Myotonic Dystrophy Protein kinase (DMPK) protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
||Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.||Kaliman P,Catalucci D,Lam JT,Kondo R,Gutiérrez JC,Reddy S,Palacín M,Zorzano A,Chien KR,Ruiz-Lozano P||The Journal of biological chemistry (280:8016)||2005|
|Rat||Not Cited||Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.||Kaliman P,Catalucci D,Lam JT,Kondo R,Gutiérrez JC,Reddy S,Palacín M,Zorzano A,Chien KR,Ruiz-Lozano P||The Journal of biological chemistry (280:8016)||2005|
DM; DM-kinase; DM1; DM1PK; DMK; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; MDPK; myotonic dystrophy protein kinase; myotonin-protein kinase
DM; Dm15; DMK; Dmpk; MDPK; MT-PK