|ELISA (ELISA)||Assay Dependent|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Immunofluorescence (IF)||See 1 publications below|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Mouse|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide from the C-terminal region of the mouse Myotonic Dystrophy Protein kinase (DMPK) protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DM; DM-kinase; DM1; DM1PK; DMK; DMPK; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; MDPK; MT-PK; Myotonic dystrophy protein kinase; Myotonin-protein kinase
Gene Aliases: DM; Dm15; DMK; Dmpk; MDPK; MT-PK
UniProt ID: (Mouse) P54265
Entrez Gene ID: (Mouse) 13400
Molecular Function: annexin calcium-binding protein calmodulin intracellular calcium-sensing protein kinase non-receptor serine/threonine protein kinase protein kinase transfer/carrier protein transferase
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