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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 286 and 573 of Human DMTF1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29466 targets DMTF1 in WB applications and shows reactivity with Human and mouse samples.
The PA5-29466 immunogen is recombinant fragment corresponding to a region within amino acids 286 and 573 of Human DMTF1.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; cyclin-D-binding Myb-like transcription factor 1; cyclin-D-interacting Myb-like protein 1; D-interacting myb-like protein; DMP1; DMTF; hDMP1; hDMTF1; mDmp1
Dimp; DMP1; DMTF; DMTF1; hDMP1; MRUL