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DNA polymerase alpha Polyclonal Antibody
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Product Details
BS-6166R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human DPOLA/DNA polymerase alpha, amino acids 1231-1350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol alpha, beta, delta and epsilon are involved in DNA replication and repair. DNA pol delta and DNA pol epsilon are multisubunit enzymes, with DNA pol delta consisting of two subunits: p125, which interacts with the sliding DNA clamp protein PCNA; and p50. The nuclear-encoded DNA pol gamma is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol zeta is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol theta is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA pol alpha; DNA polymerase alpha 1, 180 kDa; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha subunit I; G7a/Bat6Hom; polymerase (DNA directed), alpha 1, catalytic subunit; polymerase (DNA) alpha 1, catalytic subunit; polymerase (DNA-directed), alpha (70kD); polymerase, alpha 1; unnamed protein product
Gene Aliases: AW321876; NSX; p180; PDR; POLA; POLA1; VEODS
UniProt ID: (Human) P09884, (Mouse) P33609, (Rat) O89042
Entrez Gene ID: (Human) 5422, (Mouse) 18968, (Rat) 85241
nucleotide binding
nucleic acid binding
DNA binding
chromatin binding
DNA replication origin binding
single-stranded DNA binding
DNA-directed DNA polymerase activity
protein binding
zinc ion binding
transferase activity
nucleotidyltransferase activity
protein kinase binding
DNA polymerase activity
metal ion binding
nucleoside binding
double-stranded DNA binding
DNA primase activity
3'-5' exonuclease activity
purine nucleotide binding
pyrimidine nucleotide binding
protein heterodimerization activity
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
DNA metabolism protein
nucleic acid metabolism protein
DNA synthesis involved in DNA repair
DNA replication
DNA-dependent DNA replication
DNA replication, synthesis of RNA primer
DNA replication initiation
DNA strand elongation involved in DNA replication
leading strand elongation
lagging strand elongation
DNA repair
nucleotide-excision repair
double-strand break repair via nonhomologous end joining
regulation of type I interferon production
mitotic DNA replication initiation
DNA synthesis involved in UV-damage excision repair
cell proliferation
DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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