Proteintech

DNA2 Polyclonal Antibody

DNA2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

DNA2 Antibody (18727-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 18727-1-AP (DNA2 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

DNA2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

DNA2 Antibody in Immunoprecipitation (IP)

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Product Details

18727-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

1:300

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to DNA2.

Target Information

DNA2 is a conserved helicase/nuclease involved in themaintenance of mitochondrial and nuclear DNA stability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells.

Communications biology

Noyes C,Kitajima S,Li F,Suita Y,Miriyala S,Isaac S,Ahsan N,Knelson E,Vajdi A,Tani T,Thai TC,Xu D,Murai J,Tapinos N,Takahashi C,Barbie DA,Yajima M

Wed Jan 18 00:00:00 EST 2023

Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling.

Nature cell biology

Emam A,Wu X,Xu S,Wang L,Liu S,Wang B

Fri Jul 01 00:00:00 EDT 2022

Stalled replication fork protection limits cGAS-STING and P-body-dependent innate immune signalling.

Nature cell biology

Emam A,Wu X,Xu S,Wang L,Liu S,Wang B

Fri Jul 01 00:00:00 EDT 2022

Increased Resection at DSBs in G₂-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

Cells

Xiao H,Li F,Mladenov E,Soni A,Mladenova V,Pan B,Dueva R,Stuschke M,Timmermann B,Iliakis G

Sat Jul 02 00:00:00 EDT 2022

Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer.

Disease markers

Han Y,Zhang Z,Wang Z,Sun S

Fri Oct 29 00:00:00 EDT 2021

Increased Expression of DNA2 Was Linked to Poor Prognosis in Breast Cancer.

Disease markers

Han Y,Zhang Z,Wang Z,Sun S

Fri Oct 29 00:00:00 EDT 2021

Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.

Frontiers in molecular biosciences

Lu Y,Zhou X,Liu Z,Wang W,Li F,Fu W

Tue Nov 03 00:00:00 EST 2020

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.

Genes & development

Xu S,Wu X,Wu L,Castillo A,Liu J,Atkinson E,Paul A,Su D,Schlacher K,Komatsu Y,You MJ,Wang B

Sat Jul 15 00:00:00 EDT 2017

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.

Genes & development

Xu S,Wu X,Wu L,Castillo A,Liu J,Atkinson E,Paul A,Su D,Schlacher K,Komatsu Y,You MJ,Wang B

Sat Jul 15 00:00:00 EDT 2017

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models.

BMC cancer

Hervouet E,Claude-Taupin A,Gauthier T,Perez V,Fraichard A,Adami P,Despouy G,Monnien F,Algros MP,Jouvenot M,Delage-Mourroux R,Boyer-Guittaut M

Sat Oct 17 00:00:00 EDT 2015

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models.

BMC cancer

Hervouet E,Claude-Taupin A,Gauthier T,Perez V,Fraichard A,Adami P,Despouy G,Monnien F,Algros MP,Jouvenot M,Delage-Mourroux R,Boyer-Guittaut M

Sat Oct 17 00:00:00 EDT 2015

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining.

Cell cycle (Georgetown, Tex.)

Tsai FL,Kai M

Mon Jul 20 00:00:00 EDT 2015

The checkpoint clamp protein Rad9 facilitates DNA-end resection and prevents alternative non-homologous end joining.

Cell cycle (Georgetown, Tex.)

Tsai FL,Kai M

Mon Jul 20 00:00:00 EDT 2015

Bioinformatics

Protein Aliases: DNA replication ATP-dependent helicase-like homolog; DNA replication ATP-dependent helicase/nuclease DNA2; DNA replication helicase 2 homolog; DNA2-like helicase; hDNA2

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Gene Aliases: DNA2; DNA2L; E130315B21Rik; hDNA2; KIAA0083

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UniProt ID: (Human) P51530, (Mouse) Q6ZQJ5

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Entrez Gene ID: (Human) 1763, (Mouse) 327762

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Function(s)

DNA binding DNA helicase activity helicase activity nuclease activity protein binding ATP binding ATPase activity site-specific endodeoxyribonuclease activity, specific for altered base 5'-flap endonuclease activity 5'-3' DNA helicase activity single-stranded DNA-dependent ATPase activity metal ion binding 4 iron, 4 sulfur cluster binding nucleotide binding catalytic activity endonuclease activity hydrolase activity phosphoric ester hydrolase activity T/G mismatch-specific endonuclease activity retroviral 3' processing activity iron-sulfur cluster binding

Process(es)

DNA replication checkpoint DNA double-strand break processing DNA replication mitochondrial DNA replication DNA repair base-excision repair cellular response to DNA damage stimulus metabolic process DNA duplex unwinding DNA replication, Okazaki fragment processing DNA replication, removal of RNA primer mitochondrial DNA repair positive regulation of DNA replication nucleic acid phosphodiester bond hydrolysis telomere maintenance via recombination telomere maintenance DNA synthesis involved in DNA repair strand displacement regulation of signal transduction by p53 class mediator mitotic telomere maintenance via semi-conservative replication

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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DNA2 Polyclonal Antibody

DNA2 Antibody (18727-1-AP) in ICC/IF

Product Details

18727-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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