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Proteintech
DNAJB2 Polyclonal Antibody
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Product Details
10838-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNAJB2 Fusion Protein Ag1271 (1-324 aa encoded by BC011609)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects both isoforms of DNAJB2 with MW between 32-40 kDa.
Immunogen sequence: MASYYEILD VPRSASADDI KKAYRRKALQ WHPDKNPDNK EFAEKKFKEV AEAYEVLSDK HKREIYDRYG REGLTGTGTG PSRAEAGSGG PGFTFTFRSP EEVFREFFGS GDPFAELFDD LGPFSELQNR GSRHSGPFFT FSSSFPGHSD FSSSSFSFSP GAGAFRSVST STTFVQGRRI TTRRIMENGQ ERVEVEEDGQ LKSVTINGVP DDLALGLELS RREQQPSVTS RSGGTQVQQT PASCPLDSDL SEDEDLQLAM AYSLSEMEAA GKKPAGGREA QHRRQGRPKA QHQDPGLGGT QEGARGEATK RSPSPEEKAS RCLIL (1-324 aa encoded by BC011609)
Target Information
The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of the J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. The proteins contain cysteine rich regions that are composed of zinc fingers that form a peptide binding domain responsible for the chaperone function. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. DnaJB2 (DnaJ homolog subfamily B member 2), also known as HSJ1 or HSPF3, is expressed almost exclusively in the brain, with the highest levels in the frontal cortex and hippocampus. Two isoforms are produced due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DnaJ (Hsp40) homolog, subfamily B, member 10; DnaJ (Hsp40) homolog, subfamily B, member 2; DnaJ homolog subfamily B member 10; DnaJ homolog subfamily B member 2; dnaJ protein homolog 1; Heat shock 40 kDa protein 3; Heat shock protein J1; heat shock protein, DNAJ-like 1; heat shock protein, neuronal DNAJ-like 1; heat-shock protein DnaJ homolog; HSJ-1; mDj8; unnamed protein product
Gene Aliases: 2700059H22Rik; CMT2T; Dnajb10; DNAJB2; DSMA5; HMNR5; HSJ-1; HSJ1; HSPF3; mDj8
UniProt ID: (Human) P25686, (Mouse) Q9QYI5
Entrez Gene ID: (Human) 3300, (Mouse) 56812, (Rat) 689593
ATPase activator activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ubiquitin binding
unfolded protein binding
chaperone binding
proteasome binding
protein serine/threonine kinase binding
ubiquitin-dependent protein binding
protein transporter activity
chaperone
protein folding
response to unfolded protein
negative regulation of cell proliferation
negative regulation of cell growth
regulation of protein ubiquitination
positive regulation of protein ubiquitination
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ATPase activity
regulation of protein localization
ERAD pathway
protein refolding
proteasome-mediated ubiquitin-dependent protein catabolic process
neuron cellular homeostasis
negative regulation of inclusion body assembly
negative regulation of protein deubiquitination
regulation of protein folding
ER-associated ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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