This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: FDSPFEFGFT FRNPDDVFRE FFGGRDPFSF DFFEDPFEDF FGNRRGPRGS RSRGTGSFFS AFSGFPSFGS GFSSFDTGFT SFGSLGHGGL TSFSSTS
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 94%.
In prokaryotes, the heat shock response is characterized by the induction of several proteins including DnaJ, DnaK, GroEL and GroES. DnaK is a member of the HSP70 family, and like other members, exhibits ATPase activity which facilitates the release of bound proteins and disaggregation of protein complexes within the cell. Members of this protein group serve as molecular chaperones. Levels of DnaJ and DnaK are closely linked and, in E. coli, are constituents of a single operon. DnaJ regulates DnaK in several different systems. Relative to DnaK, the level of DnaJ synthesis is quite low.
Studies have shown that DnaJ and DnaK, together with GrpE, cooperatively interact with firefly luciferase as it unfolds during thermal denaturation allowing renaturation of the protein upon return to normal temperatures. Also, DnaK together with DnaJ stimulates the binding of RepA initiator protein to the origin of P1 phage in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DJ4; DnaJ; DnaJ (Hsp40) homolog, subfamily B, member 6; DnaJ homolog subfamily B member 6; DnaJ-like 2 protein; Heat shock protein J2; HHDJ1; HSJ-2; HSJ2; MRJ; MSJ-1
Gene Aliases: DJ4; DnaJ; DNAJB6; HHDJ1; HSJ-2; HSJ2; LGMD1D; LGMD1E; MRJ; MSJ-1; MSJ1
UniProt ID: (Human) O75190
Entrez Gene ID: (Human) 10049