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The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
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Protein Aliases: DnaJ (Hsp40) homolog, subfamily C, member 1; DnaJ (Hsp40) homolog, subfamily C, member 1-like; DnaJ homolog subfamily C member 1; DnaJ protein homolog MTJ1; DnaJ-like protein; DnaJ-like protein 1
Gene Aliases: 4733401K02Rik; AA960110; D230036H06Rik; DNAJC1; DNAJL1; ERdj1; ERj1p; HTJ1; MTJ1
UniProt ID: (Human) Q96KC8, (Mouse) Q61712
Entrez Gene ID: (Human) 64215, (Mouse) 13418, (Rat) 100360412
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