|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 84 and 309 of Human DNASE2B|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31391 targets DNASE2B in WB applications and shows reactivity with Human samples.
The PA5-31391 immunogen is recombinant fragment corresponding to a region within amino acids 84 and 309 of Human DNASE2B.
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deoxyribonuclease II beta; Deoxyribonuclease-2-beta; DLAD; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; Endonuclease DLAD; lysosomal DNase II
Gene Aliases: DLAD; DNASE2B
UniProt ID: (Human) Q8WZ79
Entrez Gene ID: (Human) 58511
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.