Product References
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
EBioMedicine
Lopusna K,Nowialis P,Opavska J,Abraham A,Riva A,Opavsky R
PA1-884 was used in Western Blot to study a role of Dnmt3b's catalytic activity in development and cancer using a mouse model expressing catalytically inactive Dnmt3b (Dnmt3bCI).
Fri Jan 01 00:00:00 EST 2021
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
EBioMedicine
Lopusna K,Nowialis P,Opavska J,Abraham A,Riva A,Opavsky R
PA1-884 was used in Western Blot to study a role of Dnmt3b's catalytic activity in development and cancer using a mouse model expressing catalytically inactive Dnmt3b (Dnmt3bCI).
Fri Jan 01 00:00:00 EST 2021
Epigenetic Regulation of CDH1 Is Altered after HOXB7-Silencing in MDA-MB-468 Triple-Negative Breast Cancer Cells.
Genes
Paço A,Leitão-Castro J,Freitas R
PA1-884 was used in Western Blot to explore the contribution of HOXB7 deregulation to the aggressiveness of certain cancers such as triple-negative breast cancers.
Sun Oct 03 00:00:00 EDT 2021
Epigenetic Regulation of CDH1 Is Altered after HOXB7-Silencing in MDA-MB-468 Triple-Negative Breast Cancer Cells.
Genes
Paço A,Leitão-Castro J,Freitas R
PA1-884 was used in Western Blot to explore the contribution of HOXB7 deregulation to the aggressiveness of certain cancers such as triple-negative breast cancers.
Sun Oct 03 00:00:00 EDT 2021
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
The Journal of biological chemistry
Lopusna K,Nowialis P,Opavska J,Abraham A,Riva A,Haney SL,Opavsky R
PA1-884 was used in Western Blotting to study the Dnmt3b activity in vivo by generating Dnmt3b+/- mice expressing one wild-type allele as well as Dnmt3b+/CI and Dnmt3bCI/CI mice where one or both alleles express catalytically inactive Dnmt3bCI.
Tue Aug 31 00:00:00 EDT 2021
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
The Journal of biological chemistry
Lopusna K,Nowialis P,Opavska J,Abraham A,Riva A,Haney SL,Opavsky R
PA1-884 was used in Western Blotting to study the Dnmt3b activity in vivo by generating Dnmt3b+/- mice expressing one wild-type allele as well as Dnmt3b+/CI and Dnmt3bCI/CI mice where one or both alleles express catalytically inactive Dnmt3bCI.
Tue Aug 31 00:00:00 EDT 2021
Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions.
Nature communications
Nowialis P,Lopusna K,Opavska J,Haney SL,Abraham A,Sheng P,Riva A,Natarajan A,Guryanova O,Simpson M,Hlady R,Xie M,Opavsky R
PA1-884 was used in Western Blotting to highlight that Dnmt3b is a multifaceted protein that serves as an enzyme, an accessory factor for other methyltransferases, and as a transcriptional repressor in mouse embryogenesis.
Thu Sep 26 00:00:00 EDT 2019
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
PA1-884 was used in Western Blotting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells.
Nucleic acids research
Termanis A,Torrea N,Culley J,Kerr A,Ramsahoye B,Stancheva I
PA1-884 was used in western blot determine if the capacity for de novo DNA methylation of developmentally regulated loci is preserved in differentiated somatic cells
Mon Sep 19 00:00:00 EDT 2016
G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells.
Cell reports
Zhang T,Termanis A,Özkan B,Bao XX,Culley J,de Lima Alves F,Rappsilber J,Ramsahoye B,Stancheva I
PA1-884 was used in western blot to characterize the G9a/GLP complex and how it maintains imprinted DNA methylation in embryonic stem cells
Tue Apr 05 00:00:00 EDT 2016
LSH and G9a/GLP complex are required for developmentally programmed DNA methylation.
Genome research
Myant K,Termanis A,Sundaram AY,Boe T,Li C,Merusi C,Burrage J,de Las Heras JI,Stancheva I
PA1-884 was used in western blot to investigate the role of LSH and G9a/GLP in DNA methylation during development
Sat Jan 01 00:00:00 EST 2011
De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.
The Journal of biological chemistry
Shamay M,Greenway M,Liao G,Ambinder RF,Hayward SD
PA1-884 was used in western blot to study the interaction between de novo DNA methyltransferase DNMT3b and NEDD8-modified proteins
Fri Nov 19 00:00:00 EST 2010
LSH cooperates with DNA methyltransferases to repress transcription.
Molecular and cellular biology
Myant K,Stancheva I
PA1-884 was used in western blot to investigate the role of LSH during DNA methylation by DNA methyltransferases in mammals
Tue Jan 01 00:00:00 EST 2008