Keep as concentrated solution.
Positive Control: HeLa, HeLa nuclear, GFP-tagged DNMT3B-transfested 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA (cytosine-5-)-methyltransferase 3 beta Antibody; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; Dnmt3b; ICF Antibody; ICF1 Antibody; M.HsaIIIB Antibody
Gene Aliases: DNMT3B; ICF; ICF1; M.HsaIIIB
UniProt ID: (Human) Q9UBC3