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Invitrogen
DOC2A Polyclonal Antibody
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FIGURE: 1 / 2
DOC2A Antibody (PA5-31345) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of DOC2A was performed in DIV9 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: DOC2A Polyclonal Antibody (Product # PA5-31345) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
Product Details
PA5-31345
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human DOC2A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Mouse brain.
Predicted reactivity: Mouse (97%), Rat (97%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Doc2; Doc2-alpha; double C2, alpha; Double C2-like domain-containing protein alpha; double C2-like domains, alpha; unnamed protein product
Gene Aliases: Doc2; DOC2A
UniProt ID: (Human) Q14183, (Rat) P70611, (Mouse) Q7TNF0
Entrez Gene ID: (Human) 8448, (Rat) 65031, (Mouse) 13446
synaptic vesicle exocytosis
regulation of calcium ion-dependent exocytosis
exocytosis
chemical synaptic transmission
calcium ion-regulated exocytosis of neurotransmitter
nervous system development
positive regulation of calcium ion-dependent exocytosis
spontaneous neurotransmitter secretion
calcium-dependent activation of synaptic vesicle fusion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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