This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
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Protein Aliases: 180 kDa protein downstream of CRK; dedicator of cyto-kinesis 1; Dedicator of cytokinesis protein 1; dock 180; DOCK180; DOwnstream of CrK; RP11-82L9.1
Gene Aliases: 9130006G06Rik; AI854900; ced5; D630004B07Rik; DOCK1; DOCK180
Molecular Function: guanyl-nucleotide exchange factor