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Product Details
PA5-92030
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1551-1830 of human DOCK2 (NP_0049371)
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806357
Product Specific Information
Positive Samples: Jurkat; Cellular Location: Cytoplasm, Endomembrane system, Peripheral membrane protein, cytoskeleton^M
^M
Immunogen sequence: FTEEYVRDHP EDQDKLTHLK DLIAWQIPFL GAGIKIHEKR VSDNLRPFHD RMEECFKNLK MKVEKEYGVR EMPDFDDRRV GRPRSMLRSY RQMSIISLAS MNSDCSTPSK PTSESFDLEL ASPKTPRVEQ EEPISPGSTL PEVKLRRSKK RTKRSSVVFA DEKAAAESDL KRLSRKHEFM SDTNLSEHAA IPLKASVLSQ MSFASQSMPT IPALALSVAG IPGLDEANTS PRLSQTFLQL SDGDKKTLTR KKVNQFFKTM LASKSAEEGK QIPDSLSTDL
Target Information
The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dedicator of cyto-kinesis 2; Dedicator of cytokinesis protein 2; FLJ46592; Protein Hch
Gene Aliases: AI662014; AW122239; CED-5; DOCK2; Hch; IMD40; KIAA0209; MBC
UniProt ID: (Human) Q92608, (Mouse) Q8C3J5
Entrez Gene ID: (Human) 1794, (Mouse) 94176
membrane raft polarization
establishment of T cell polarity
immunological synapse formation
myeloid dendritic cell activation involved in immune response
chemotaxis
small GTPase mediated signal transduction
actin cytoskeleton organization
positive regulation of GTPase activity
macropinocytosis
positive thymic T cell selection
negative thymic T cell selection
alpha-beta T cell proliferation
regulation of defense response to virus by virus
positive regulation of phagocytosis
cytoskeleton organization
positive regulation of Rac protein signal transduction
T cell proliferation
T cell activation
alpha-beta T cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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