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Invitrogen
DOCK7 Polyclonal Antibody
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Product Details
PA5-103779
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DOCK7(Accession Q96N67), corresponding to amino acid residues D197-P247.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DOCK7.
Target Information
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dedicator of cytokinesis protein 7; guanine nucleotide exchange factor for Rac GTPases; guanine-nucleotde exchange factor; guanine-nucleotide exchange factor; protein moonlight; unnamed protein product
Gene Aliases: 3110056M06Rik; DEE23; DOCK7; EIEE23; Gm430; KIAA1771; m; ZIR2
UniProt ID: (Human) Q96N67
Entrez Gene ID: (Human) 85440, (Mouse) 67299, (Rat) 313388
microtubule cytoskeleton organization
small GTPase mediated signal transduction
nervous system development
axonogenesis
Rac protein signal transduction
interkinetic nuclear migration
cell differentiation
neuron projection development
regulation of Rho protein signal transduction
establishment of neuroblast polarity
regulation of neurogenesis
negative regulation of cold-induced thermogenesis
positive regulation of vascular associated smooth muscle cell migration
hematopoietic progenitor cell differentiation
multicellular organism development
positive regulation of peptidyl-serine phosphorylation
pigmentation
activation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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