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Invitrogen
DOG-1 Polyclonal Antibody
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FIGURE: 1 / 6
DOG-1 Antibody (PA5-119679) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of of DOG1 in HepG2 cells (green). Formalin fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 10 minutes at room temperature and blocked with 1% Blocker BSA for 15 minutes at room temperature. Cells were probed with DOG-1 Polyclonal Antibody (Product # PA5-119679) at a dilution of 1:50 for 1 hour at room temperature, washed with PBS. Alexa Fluor 488 Goat anti-Rabbit IgG was used as the secondary antibody at 1:1,000 dilution. The nuclear counter stain is DAPI (blue).
Product Details
PA5-119679
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within C-terminal human DOG-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: PC-3M cell lysates, A549, HepG2, human liver carcinoma tissue, human seminal pouch tissue.
Subcellular Location: Cell membrane, cytoplasm.
Target Information
DOG-1, the novel marker, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of kit or PDGFR alpha mutation status.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ano1; anoctamin 1, calcium activated chloride channel; Anoctamin-1; AT5G45830; ATDOG1; Ca2+-activated Cl- channel; cacium activated chloride channel; calcium activated chloride channel; DELAY OF GERMINATION 1; Discovered on gastrointestinal stromal tumors protein 1; FLJ10261; GAAS5; germination ability after storage 5; GLUCOSE SENSING QTL 5; GSQ5; K15I22.3; K15I22_3; membrane protein; oral cancer overexpressed 2; Oral cancer overexpressed protein 2; Transmembrane protein 16A; transmembrane protein 16A (eight membrane-spanning domains); Tumor-amplified and overexpressed sequence 2; unnamed protein product
Gene Aliases: ANO1; DOG1; INDMS; MYMY7; ORAOV2; TAOS2; TMEM16A
UniProt ID: (Human) Q5XXA6
Entrez Gene ID: (Human) 55107
receptor binding
calcium activated cation channel activity
intracellular calcium activated chloride channel activity
voltage-gated chloride channel activity
chloride channel activity
protein binding
iodide transmembrane transporter activity
identical protein binding
protein homodimerization activity
metal ion binding
protein dimerization activity
ion transport
chloride transport
phospholipase C-activating G-protein coupled receptor signaling pathway
iodide transport
ion transmembrane transport
cellular response to heat
detection of temperature stimulus involved in sensory perception of pain
mucus secretion
protein localization to membrane
cation transmembrane transport
glial cell projection elongation
cellular response to peptide
chloride transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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