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Proteintech
DOK6 Polyclonal Antibody
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Product Details
14108-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DOK6 Fusion Protein Ag5254 (75-331 aa encoded by BC008583)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TKKHAVAII FHDETSKTFA CESELEAEEW CKHLCMECLG TRLNDISLGE PDLLAAGVQR EQNERFNVYL MPTPNLDIYG ECTMQITHEN IYLWDIHNAK VKLVMWPLSS LRRYGRDSTW FTFESGRMCD TGEGLFTFQT REGEMIYQKV HSATLAIAEQ HERLMLEMEQ KARLQTSLTE PMTLSKSISL PRSAYWHHIT RQNSVGEIYS LQGHGFGSSK MSRAQTFPSY APEQSEEAQQ PLSRSSSYGF SYSSSLIQ (75-331 aa encoded by BC008583 )
Target Information
DOK-6 (docking protein 6), is a novel member of the Dok-4/5 subclass of the p62 Dok family of intracellular adaptor molecules. Dok-6 is highly expressed in the developing central nervous system and is co-expressed with Ret in several locations, including sympathetic, sensory, and parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys. Pull-down assays using the Dok-6 phosphotyrosine binding (PTB) domain and GDNF-activated Ret indicate that Dok-6 binds to the phosphorylated Ret Tyr(1062) residue. Moreover, ligand activation of Ret resulted in phosphorylation of tyrosine residue(s) located within the unique C terminus of Dok-6 predominantly through a Src-dependent mechanism, indicating that Dok-6 is a substrate of the Ret-Src signaling pathway. (Crowder RJ, Enomoto H, Yang M, Johnson EM Jr, Milbrandt J. Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. J Biol Chem. 2004 Oct 1;279(40):42072-81. Epub 2004 Jul 30. It is also known as DOK6, HsT3226, MGC20785 or IRS. 0.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adaptor protein; Docking protein 6; Downstream of tyrosine kinase 6; downstream of tyrosine kinases 6; unnamed protein product
Gene Aliases: Dok-6; DOK5L; DOK6; HsT3226; RGD1564376
UniProt ID: (Human) Q6PKX4, (Mouse) Q2MHE5
Entrez Gene ID: (Human) 220164, (Mouse) 623279, (Rat) 498898
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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