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Invitrogen
DOK7 Polyclonal Antibody
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FIGURE: 1 / 6
DOK7 Antibody (PA5-95620) in IHC (P)
Immunohistochemistry (Paraffin) analysis of DOK7 in paraffin-embedded section of human skeletal muscle tissue using DOK7 Polyclonal Antibody (Product # PA5-95620). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight... View More
Product Details
PA5-95620
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence of human DOK7 (STVEERVAQEALETLQLEKRLSLLSHAGR).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human MCF-7 whole cell, human RT4 whole cell, rat skeletal muscle tissue lysates, rat brain tissue lysates, rat heart tissue lysates, rat L6 whole cell lysates, mouse skeletal muscle tissue lysates, mouse brain tissue lysates, mouse heart tissue lysates, mouse C2C12 whole cell lysates. IHC: human skeletal muscle, rat heart. Flow: RT4 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Downstream of tyrosine kinase 7; oncoprotein induced transcript 5; Protein Dok-7
Gene Aliases: A930013K19Rik; AW049091; C4orf25; CMS10; CMS1B; Dok-7; DOK7; EF-12; Oit5; RGD1566416
UniProt ID: (Human) Q18PE1, (Mouse) Q18PE0
Entrez Gene ID: (Human) 285489, (Mouse) 231134, (Rat) 305448
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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