|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 228 of Human DOM3Z|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
PA5-29505 targets DOM3Z in IF and WB applications and shows reactivity with Human samples.
The PA5-29505 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 228 of Human DOM3Z.
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
PA5-29505 was used in western blot to identify the enzymes and mechanisms responsible for human telomerase RNA degradation
|Shukla S,Schmidt JC,Goldfarb KC,Cech TR,Parker R||Nature structural and molecular biology (23:286)||2016|