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Proteintech
DOPA decarboxylase Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-10166
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DOPA decarboxylase fusion protein Ag0219
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: WLGKMLELP KAFLNEKAGE GGGVIQGSAS EATLVALLAA RTKVIHRLQA ASPELTQAAI MEKLVAYSSD QAHSSVERAG LIGGVKLKAI PSDGNFAMRA SALQEALERD KAAGLIPFFM VATLGTTTCC SFDNLLEVGP ICNKEDIWLH VDAAYAGSAF ICPEFRHLLN GVEFADSFNF NPHKWLLVNF DCSAMWVKKR TDLTGAFRLD PTYLKHSHQD SGLITDYRHW QIPLGRRFRS LKMWFVFRMY GVKGLQAYIR KHVQLSHEFE
Target Information
DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AADC; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); dopa decarboxylase (aromatic L-amino acid decarboxylase) isoform DDC_1; dopa decarboxylase (aromatic L-amino acid decarboxylase) isoform DDC_2; HGNC:2719; L-Dopa decarboxylase; unnamed protein product
Gene Aliases: AADC; DDC
UniProt ID: (Human) P20711, (Mouse) O88533, (Rat) P14173
Entrez Gene ID: (Human) 1644, (Mouse) 13195, (Rat) 24311
aromatic-L-amino-acid decarboxylase activity
protein binding
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
enzyme binding
pyridoxal phosphate binding
5-hydroxy-L-tryptophan decarboxylase activity
L-dopa decarboxylase activity
catalytic activity
amino acid binding
protein domain specific binding
decarboxylase
kidney development
cellular amino acid metabolic process
catecholamine metabolic process
response to toxic substance
gene expression
carboxylic acid metabolic process
cellular biogenic amine biosynthetic process
dopamine biosynthetic process
catecholamine biosynthetic process
serotonin biosynthetic process
aminergic neurotransmitter loading into synaptic vesicle
circadian rhythm
multicellular organism aging
isoquinoline alkaloid metabolic process
cellular response to drug
dopamine metabolic process
response to pyrethroid
phytoalexin metabolic process
cellular response to alkaloid
cellular response to growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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