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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 208 of Human DPM1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28381 targets DPM1 in WB applications and shows reactivity with Human samples.
The PA5-28381 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 208 of Human DPM1.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CDGIE; dolichol monophosphate mannose synthase; dolichol-phosphate mannose synthase; dolichol-phosphate mannose synthase subunit 1; dolichol-phosphate mannosyltransferase; dolichyl-phosphate beta-D-mannosyltransferase; dolichyl-phosphate beta-D-mannosyltransferase subunit 1; dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit; DPM synthase complex, catalytic subunit; DPM synthase subunit 1; mannose-P-dolichol synthase; mannose-P-dolichol synthase subunit 1; MPD synthase; MPD synthase subunit 1; MPDS
CDGIE; DPM1; MPDS