Immunogen sequence: SSPPPLDPGQ GFGKTPPLNM LPHFGGAGSC LPRTHPWGFP VHPSRLPVSN LWVSWC
Highest antigen sequence identity to the following orthologs: Mouse - 38%, Rat - 38%.
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dolichol phosphate-mannose biosynthesis regulatory protein; Dolichol-phosphate mannose synthase subunit 2; DPM synthase complex subunit; DPM synthase subunit 2
Gene Aliases: CDG1U; DPM2; My026
UniProt ID: (Human) O94777
Entrez Gene ID: (Human) 8818