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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide: L(521) K E A I L K K K I G K P E I K I L H(539)|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4385 detects DPP10 in human samples.
PA1-4385 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~75 kDa protein representing DPP10. Oligermization and differential glycosylation produces other bands as observed with other DPP family members.
PA1-4385 immunizing peptide corresponds to amino acid residues 521-539 of human DPP10.
A novel gene, DPP10, encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy. The DPP10 protein shares features with members of the S9B family of DPP serine proteases, which includes DPP4, a widely expressed enzyme that plays a central role in chemokine processing as part of the innate immune system. The locus displays a complex pattern of transcript splicing, with eight alternate first axons; four of which localize within the LD block strongly associated with asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
dipeptidyl peptidase 10; Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2; dipeptidyl-peptidase 10 (inactive); dipeptidyl-peptidase 10 (non-functional); DPL2; DPP X; DPRP-3; Inactive dipeptidyl peptidase 10
DPL2; DPP10; DPPY; DPRP-3; DPRP3; KIAA1492