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Proteintech
DPP4/CD26 Polyclonal Antibody
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Product Details
32397-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Concentration
500 µg/mL
Amount
75 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: SKDEAAADSR RTYSLADYLK STFRVKSYSL WWVSDFEYLY KQENNILLLN AEHGNSSIFL ENSTFESFGY HSVSPDRLFV LLEYNYVKQW RHSYTASYNI YDVNKRQLIT EEKIPNNTQW ITWSPEGHKL AYVWKNDIYV KVEPHLPSHR ITSTGEENVI YNGITDWVYE EEVFGAYSAL WWSPNNTFLA YAQFNDTGVP LIEYSFYSDE SLQYPKTVWI PYPKAGAVNP TVKFFIVNID SLSSSSSAAP IQIPAPASVA RGDHYLCDVV WATEERISLQ WLRRIQNYSV MAICDYDKIN LTWNCPSEQQ HVEMSTTGWV GRFRPAEPHF TSDGSSFYKI ISDKDGYKHI CHFPKDKKDC TFITKGAWEV ISIEALTSDY LYYISNQYKE MPGGRNLYKI QLTDHTNVKC LSCDLNPERC QYYAVSFSKE AKYYQLGCWG PGLPLYTLHR STDHKELRVL EDNSALDRML QDVQMPSKKL DFIVLNETRF WYQMILPPHF DKSKKYPLLL DVYAGPCSQK ADASFRLNWA TYLASTENII VASFDGRGSG YQGDKIMHAI NRRLGTLEVE DQIEAARQFV KMGFVDSKRV AIWGWSYGGY VTSMVLGSGS GVFKCGIAVA PVSRWEYYDS VYTERYMGLP IPEDNLDHYR NSTVMSRAEH FKQVEYLLIH GTADDNVHFQ QSAQISKALV DAGVDFQAMW YTDEDHGIAS STAHQHIYSH MSHFLQQCFS LH
Target Information
CD26 (dipeptidyl peptidase IV, DPP IV), adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. CD26 identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. Further, CD26 is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Alterations in CD26 peptidase activity are characteristic of malignant transformation, and the enzymatic activity increases dramatically with tumor grade and severity. CD26 is expressed in various blood cell types, but also in cells that are histogenetically related to activated fibroblasts. Alterations in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bile canaliculus domain-specific membrane glycoprotein; CD26; Dipeptidyl peptidase 4; Dipeptidyl peptidase IV; DPP IV; DPP-IV; GP110 glycoprotein; T-cell activation antigen CD26; THAM; Thymocyte-activating molecule
Gene Aliases: CD26; Dpp-4; Dpp4; DPPIV; THAM
UniProt ID: (Mouse) P28843, (Rat) P14740
Entrez Gene ID: (Mouse) 13482, (Rat) 25253
virus receptor activity
protease binding
aminopeptidase activity
serine-type endopeptidase activity
receptor binding
collagen binding
peptidase activity
serine-type peptidase activity
dipeptidyl-peptidase activity
hydrolase activity
peptide binding
identical protein binding
protein homodimerization activity
serine protease
behavioral fear response
response to hypoxia
regulation of T cell mediated immunity
proteolysis
cell adhesion
positive regulation of cell proliferation
negative regulation of extracellular matrix disassembly
T cell costimulation
regulation of cell-cell adhesion mediated by integrin
locomotory exploration behavior
psychomotor behavior
T cell activation
endothelial cell migration
viral entry into host cell
establishment of localization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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