Immunogen sequence: VKKAINDRQM PKVEYRDIEI DDYNLPMQIL KPATFTDTTH YPLLLVVDGT PGSQSVAEKF EVSWETVMVS SHGAVVVKCD G
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: dipeptidyl aminopeptidase IV-related protein; Dipeptidyl aminopeptidase-like protein 6; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; dipeptidyl peptidase IV-related protein; Dipeptidyl peptidase VI; Dipeptidyl-peptidase 6; Dipeptidylpeptidase 6; Dipeptidylpeptidase VI; DPP VI; DPP6; DPPX; inversion, Chr 5, Harwell 6, proximal; VF2
Gene Aliases: B930011P16Rik; D5Buc3; D5Buc4; D5Buc5; DPL1; DPP VI; Dpp-6; DPP6; DPPX; Gm1377; In(5)6H-p; MRD33; Peplb; Rw; VF2