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Invitrogen
DPYD Polyclonal Antibody
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FIGURE: 1 / 1
DPYD Antibody (PA5-109657) in WB
Western blot analysis of DPYD in extracts of various cell lines. Samples were incubated with DPYD Polyclonal antibody (Product # PA5-109657) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit.
Product Details
PA5-109657
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human DPYD (NP_0001012)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
31 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAPVLSKDSA DIESILALNP RTQTHATLCS TSAKKLDKKH WKRNPDKNCF NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQFAT ETLILAFSLM NHL
Target Information
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; unnamed protein product
Gene Aliases: AI315208; DHP; DHPDHASE; DPD; DPYD; DYPD; E330028L06Rik
UniProt ID: (Human) Q12882, (Mouse) Q8CHR6
Entrez Gene ID: (Human) 1806, (Mouse) 99586
nucleotide binding
uracil binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
dihydropyrimidine dehydrogenase (NADP+) activity
protein homodimerization activity
metal ion binding
flavin adenine dinucleotide binding
NADP binding
iron-sulfur cluster binding
4 iron, 4 sulfur cluster binding
catalytic activity
dihydroorotate dehydrogenase activity
dehydrogenase
oxidoreductase
metabolite interconversion enzyme
purine nucleobase catabolic process
pyrimidine nucleobase catabolic process
thymine catabolic process
uracil catabolic process
thymidine catabolic process
CMP catabolic process
dCMP catabolic process
beta-alanine biosynthetic process
UMP catabolic process
dUMP catabolic process
UMP biosynthetic process
response to nutrient
circadian rhythm
uracil metabolic process
response to drug
oxidation-reduction process
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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