This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: EVKEVLQECK TVALKRRKAS SRLENLGIPE EELLRQQQEL FAKARQQQAE LAQQEWLQMQ Q
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2-beta; negative cofactor 2; negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
Gene Aliases: DR1; NC2; NC2-BETA; NC2B
UniProt ID: (Human) Q01658
Entrez Gene ID: (Human) 1810