Search
Additional Information:
{{banner.description}}
FIGURE: 1 / 2
DRD1 Antibody (711624) in ICC/IF
HEK 293 cells stably transfected with Dopamine Receptor D1 were grown on poly-L-lysine-coated coverslips overnight. After 24 h, cells were fixed with 4% paraformaldehyde and 0.2% picric acid in phosphate buffer (pH 6.9) for 30 min at room temperature and washed several times with phosphate buffer. Specimens were permeabilized with ice-cold methanol and then incubated with Anti-GPR68 Recombinant Rabbit Superclonal™ Antibody (Product # 711624 at a concentration of 1 µg/mL). Cells were then incubated with Alexa488-conjugated secondary antibod... View More
Product Details
711624
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
2HCLC
Immunogen
Peptide corresponding to human DRD1 [aa427-aa446]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Cat, Bovine.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: D(1A) dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; DRD1; G-protein coupled receptor; unnamed protein product
Gene Aliases: D1R; DADR; DRD1; DRD1A
UniProt ID: (Human) P21728
Entrez Gene ID: (Human) 1812
temperature homeostasis
conditioned taste aversion
behavioral fear response
neuron migration
synaptic transmission, dopaminergic
response to amphetamine
protein import into nucleus
muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
dopamine receptor signaling pathway
synapse assembly
learning
memory
mating behavior
grooming behavior
locomotory behavior
adult walking behavior
feeding behavior
associative learning
visual learning
response to xenobiotic stimulus
astrocyte development
dopamine transport
cell migration
transmission of nerve impulse
neuronal action potential
dentate gyrus development
striatum development
hippocampus development
cerebral cortex GABAergic interneuron migration
positive regulation of cell migration
peristalsis
operant conditioning
synaptic transmission, glutamatergic
regulation of dopamine metabolic process
response to cocaine
vasodilation
dopamine metabolic process
maternal behavior
positive regulation of potassium ion transport
positive regulation of MAPK cascade
glucose import
habituation
sensitization
behavioral response to cocaine
positive regulation of release of sequestered calcium ion into cytosol
regulation of dopamine uptake involved in synaptic transmission
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
long-term synaptic potentiation
long term synaptic depression
cellular response to catecholamine stimulus
adenylate cyclase-activating adrenergic receptor signaling pathway
modification of postsynaptic structure
presynaptic modulation of chemical synaptic transmission
positive regulation of neuron migration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support