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          • Primary Antibodies ›
          • DRD2 Antibodies

          Proteintech

          DRD2 Polyclonal Antibody

          1 Reference
          View all (31) DRD2 antibodies

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          Cite DRD2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (2)
          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          DRD2 Antibody (22022-1-AP) in IHC (P)

          Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 22022-1-AP ( DRD2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          DRD2 Polyclonal Antibody

          Product Details

          22022-1-AP

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          DRD2 Fusion Protein Ag16821 (200-384 aa encoded by BC021195)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.36 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: VPFIVTLLV YIKIYIVLRR RRKRVNTKRS SRAFRAHLRA PLKGNCTHPE DMKLCTVIMK SNGSFPVNRR RVEAARRAQE LEMEMLSSTS PPERTRYSPI PPSHHQLTLP DPSHHGLHST PDSPAKPEKN GHAKDHPKIA KIFEIQTMPN GKTRTSLKTM SRRKLSQQKE KKATQMLAIV LGVFII (200-384 aa encoded by BC021195)

          Target Information

          The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinsons disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: D(2) dopamine receptor; D2 receptor; Dopamine 2 receptor; Dopamine D2 receptor; dopamine receptor 2; seven transmembrane helix receptor; unnamed protein product

          View more View less

          Gene Aliases: D2DR; D2R; Drd-2; DRD2

          View more View less

          UniProt ID: (Human) P14416, (Mouse) P61168

          View more View less

          Entrez Gene ID: (Human) 1813, (Mouse) 13489

          View more View less

          Function(s)
          dopamine neurotransmitter receptor activity, coupled via Gi/Go G-protein alpha-subunit binding G-protein coupled receptor activity dopamine neurotransmitter receptor activity receptor binding protein binding potassium channel regulator activity heterotrimeric G-protein binding dopamine binding ionotropic glutamate receptor binding identical protein binding macromolecular complex binding signal transducer activity drug binding protein homodimerization activity protein heterodimerization activity G-protein coupled receptor
          Process(es)
          temperature homeostasis response to hypoxia neuron migration synaptic transmission, dopaminergic startle response response to amphetamine neurological system process involved in regulation of systemic arterial blood pressure regulation of heart rate regulation of sodium ion transport G-protein coupled receptor internalization positive regulation of neuroblast proliferation positive regulation of receptor internalization cellular calcium ion homeostasis autophagy signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting dopamine receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway dopamine receptor signaling pathway neuron-neuron synaptic transmission neuroblast proliferation axonogenesis synapse assembly sensory perception of smell long-term memory grooming behavior locomotory behavior adult walking behavior feeding behavior protein localization cell proliferation negative regulation of cell proliferation associative learning visual learning response to xenobiotic stimulus response to light stimulus response to toxic substance response to iron ion regulation of dopamine secretion response to inactivity Wnt signaling pathway cell migration striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration adenohypophysis development negative regulation of cell migration peristalsis adult behavior forebrain development auditory behavior regulation of synaptic transmission, GABAergic response to estradiol positive regulation of cytokinesis circadian regulation of gene expression negative regulation of dopamine secretion response to histamine response to nicotine negative regulation of dephosphorylation intracellular signal transduction positive regulation of urine volume positive regulation of renal sodium excretion positive regulation of multicellular organism growth response to cocaine negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process drinking behavior regulation of potassium ion transport response to morphine regulation of MAPK cascade pigmentation protein kinase B signaling response to ethanol positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure negative regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion acid secretion behavioral response to cocaine behavioral response to ethanol regulation of long-term neuronal synaptic plasticity response to axon injury branching morphogenesis of a nerve arachidonic acid secretion epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of protein secretion positive regulation of neurogenesis modulation of synaptic transmission negative regulation of synaptic transmission release of sequestered calcium ion into cytosol positive regulation of multicellular organismal process negative regulation of cytosolic calcium ion concentration regulation of neurotransmitter uptake dopamine uptake involved in synaptic transmission regulation of dopamine uptake involved in synaptic transmission positive regulation of dopamine uptake involved in synaptic transmission regulation of synapse structural plasticity negative regulation of protein kinase B signaling regulation of amine transport negative regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential positive regulation of growth hormone secretion prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to ethanol regulation of locomotion involved in locomotory behavior postsynaptic modulation of chemical synaptic transmission presynaptic modulation of chemical synaptic transmission beta-arrestin-dependent dopamine receptor signaling pathway negative regulation of cellular response to hypoxia positive regulation of glial cell-derived neurotrophic factor secretion positive regulation of long-term synaptic potentiation regulation of secretion by cell hyaloid vascular plexus regression negative regulation of neuron migration negative regulation of adenylate cyclase activity chemical synaptic transmission regulation of cAMP metabolic process activation of protein kinase activity response to drug regulation of phosphoprotein phosphatase activity phosphatidylinositol metabolic process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway negative regulation of voltage-gated calcium channel activity
          It has to be done as per old AB suggested Products section.

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