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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • DRD2 Antibodies

          Bioss

          DRD2 Polyclonal Antibody

          View all (28) DRD2 antibodies

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          Cite DRD2 Polyclonal Antibody

          • Antibody Testing Data (2)
          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          DRD2 Antibody (BS-1008R) in IHC (P)

          Paraformaldehyde-fixed, paraffin embedded rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with DRD2 Polyclonal Antibody Polyclonal Antibody, Unconjugated (bs-1008R) at 1:400 overnight at 4°C, followed by an SP Kit (Rabbit) and DAB ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          DRD2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          DRD2 Antibody in Western Blot (WB)
          DRD2 Polyclonal Antibody

          Product Details

          BS-1008R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:300
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:400
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human DRD2, amino acids 201-300.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinsons disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: D(2) dopamine receptor; D2 receptor; Dopamine 2 receptor; Dopamine D2 receptor; dopamine receptor 2; dopamine receptor D2 isoform; seven transmembrane helix receptor

          View more View less

          Gene Aliases: D2DR; D2R; Drd-2; DRD2

          View more View less

          UniProt ID: (Human) P14416, (Mouse) P61168, (Rat) P61169

          View more View less

          Entrez Gene ID: (Human) 1813, (Mouse) 13489, (Rat) 24318

          View more View less

          Function(s)
          dopamine neurotransmitter receptor activity, coupled via Gi/Go adrenergic receptor activity protein binding drug binding dopamine binding ionotropic glutamate receptor binding identical protein binding protein homodimerization activity protein heterodimerization activity signal transducer activity G-protein coupled receptor activity dopamine neurotransmitter receptor activity receptor binding G-protein coupled receptor
          Process(es)
          temperature homeostasis response to hypoxia synaptic transmission, dopaminergic response to amphetamine neurological system process involved in regulation of systemic arterial blood pressure regulation of heart rate regulation of sodium ion transport G-protein coupled receptor internalization positive regulation of neuroblast proliferation positive regulation of receptor internalization negative regulation of adenylate cyclase activity adenylate cyclase-inhibiting dopamine receptor signaling pathway neuron-neuron synaptic transmission axonogenesis synapse assembly sensory perception of smell long-term memory grooming behavior locomotory behavior adult walking behavior feeding behavior protein localization negative regulation of cell proliferation associative learning visual learning response to light stimulus response to toxic substance response to iron ion regulation of dopamine secretion response to inactivity Wnt signaling pathway striatum development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration adenohypophysis development negative regulation of cell migration peristalsis regulation of cAMP metabolic process auditory behavior activation of protein kinase activity regulation of synaptic transmission, GABAergic positive regulation of cytokinesis circadian regulation of gene expression negative regulation of dopamine secretion response to histamine response to nicotine positive regulation of urine volume positive regulation of renal sodium excretion positive regulation of multicellular organism growth response to cocaine negative regulation of circadian sleep/wake cycle, sleep dopamine metabolic process response to drug regulation of potassium ion transport response to morphine pigmentation regulation of phosphoprotein phosphatase activity positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of blood pressure negative regulation of innate immune response positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process negative regulation of insulin secretion acid secretion behavioral response to cocaine behavioral response to ethanol regulation of long-term neuronal synaptic plasticity response to axon injury branching morphogenesis of a nerve arachidonic acid secretion negative regulation of protein secretion release of sequestered calcium ion into cytosol negative regulation of cytosolic calcium ion concentration regulation of dopamine uptake involved in synaptic transmission positive regulation of dopamine uptake involved in synaptic transmission regulation of synapse structural plasticity negative regulation of protein kinase B signaling negative regulation of synaptic transmission, glutamatergic positive regulation of growth hormone secretion prepulse inhibition phospholipase C-activating dopamine receptor signaling pathway negative regulation of dopamine receptor signaling pathway positive regulation of ERK1 and ERK2 cascade adenylate cyclase-activating adrenergic receptor signaling pathway regulation of locomotion involved in locomotory behavior chemical synaptic transmission, postsynaptic positive regulation of glial cell-derived neurotrophic factor secretion positive regulation of long-term synaptic potentiation negative regulation of voltage-gated calcium channel activity startle response signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway dopamine receptor signaling pathway chemical synaptic transmission adult behavior forebrain development intracellular signal transduction regulation of MAPK cascade modulation of synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway cellular potassium ion homeostasis response to ethanol positive regulation of mitotic nuclear division
          It has to be done as per old AB suggested Products section.
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