Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Marmoset (100%) Gibbon, Monkey, Rabbit (95%) Dog, Bovine, Panda, Horse, Pig (89%).
The DRD2 Dopamine Receptor is involved in the neuromodulation of appetitive behaviors. DRD2 may be linked to alcoholism and other substance-use disorders. Mutations in DRD2 in mice lead to the suppression of reward behavior with morphine and to the reduction of spontaneous movements, a phenotype resembling Parkinsons disease. Three alternatively spliced isoforms have been identified. DRD2 has been reported to be expressed in various regions of the brain, as well as in aorta, artery, eye, and spinal cord. ESTs have been isolated from normal pituitary and in brain, colon, lung, pancreas, and skeletal muscle cancer libraries.
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Protein Aliases: D(2) dopamine receptor; Dopamine 2 receptor; Dopamine D2 receptor; dopamine receptor D2 isoform; seven transmembrane helix receptor
Gene Aliases: D2DR; D2R; DRD2
UniProt ID: (Human) P14416
Entrez Gene ID: (Human) 1813
Molecular Function: G-protein coupled receptor