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Invitrogen
DRD3 Polyclonal Antibody
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Product Details
PA5-33482
Product Specifications
Species Reactivity
Bat,
Dog,
Horse,
Hamster,
Human,
Mouse,
Non-human primate,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human DRD3 / Dopamine Receptor D3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Marmoset, Mouse, Dog, Bat, Hamster, Panda, Horse, Pig (100%).
Target Information
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D(3) dopamine receptor; D3 receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopamine receptor 3; dopamine receptor D3; essential tremor 1
Gene Aliases: D3DR; D3R; DRD3; ETM1; FET1; I79_003549
UniProt ID: (Human) P35462, (Mouse) P30728
Entrez Gene ID: (Human) 1814, (Pig) 100513049, (Dog) 487984, (Horse) 100061160, (Chinese hamster) 100769070, (Mouse) 13490
dopamine neurotransmitter receptor activity, coupled via Gs
dopamine neurotransmitter receptor activity, coupled via Gi/Go
protein binding
drug binding
protein domain specific binding
D1 dopamine receptor binding
dopamine binding
signal transducer activity
G-protein coupled receptor activity
dopamine neurotransmitter receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
negative regulation of transcription from RNA polymerase II promoter
synaptic transmission, dopaminergic
response to amphetamine
regulation of blood volume by renin-angiotensin
G-protein coupled receptor internalization
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
learning or memory
learning
locomotory behavior
positive regulation of cell proliferation
visual learning
regulation of dopamine secretion
regulation of lipid metabolic process
regulation of cAMP metabolic process
negative regulation of sodium:proton antiporter activity
positive regulation of cytokinesis
circadian regulation of gene expression
response to histamine
social behavior
gastric emptying
positive regulation of renal sodium excretion
regulation of multicellular organism growth
response to cocaine
dopamine metabolic process
response to drug
response to morphine
regulation of circadian sleep/wake cycle, sleep
response to ethanol
negative regulation of blood pressure
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
acid secretion
behavioral response to cocaine
negative regulation of oligodendrocyte differentiation
arachidonic acid secretion
negative regulation of protein secretion
musculoskeletal movement, spinal reflex action
regulation of dopamine uptake involved in synaptic transmission
negative regulation of protein kinase B signaling
prepulse inhibition
negative regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of locomotion involved in locomotory behavior
signal transduction
dopamine receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
regulation of locomotion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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