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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP (PubMed:29915238, PubMed:23711155). Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions (PubMed:23711155). When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation (PubMed:19819225, PubMed:29915238). Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions (PubMed:28855639). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: developmentally regulated GTP-binding protein 1; Developmentally-regulated GTP-binding protein 1; DRG-1; GTP-binding protein; NEDD-3; Neural precursor cell expressed developmentally down-regulated protein 3; neural precursor cell expressed, developmentally down-regulated 3; TRAFAC GTPase DRG1; Translation factor GTPase DRG1
Gene Aliases: AA408859; AI132520; Drg; DRG1; Nedd-3; NEDD3
UniProt ID: (Human) Q9Y295, (Mouse) P32233
Entrez Gene ID: (Human) 4733, (Rat) 305470, (Mouse) 13494
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