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Proteintech
DSG3 Polyclonal Antibody
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Product Details
29942-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DSG3 fusion protein Ag30880
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
120 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SGQSGTMRTR HSTGGTNKDY ADGAISMNFL DSYFSQKAFA CAEEDDGQEA NDCLLIYDNE GADATGSPVG SVGCCSFIAD DLDDSFLDSL GPKFKKLAEI SLGVDGEGKE VQPPSKDSGY G
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa pemphigus vulgaris antigen; 130 kDa pemphigus vulgaris antigen homolog; Cadherin family member 6; Desmoglein-3; DKFZp686P23184; PVA; unnamed protein product
Gene Aliases: ABOLM; bal; balding; CDHF6; DSG3; PVA
UniProt ID: (Human) P32926, (Mouse) O35902
Entrez Gene ID: (Human) 1830, (Mouse) 13512
desmosome assembly
actin filament organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell migration
regulation of protein stability
adherens junction assembly
cell-cell adhesion
tight junction assembly
positive regulation of bicellular tight junction assembly
negative regulation of p38MAPK cascade
positive regulation of protein localization to adherens junction
positive regulation of protein localization to membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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