Immunogen sequence: LPPRLREEAE EQESTCPICL GEIQNAKTLE KCRHSFCEGC ITRALQVKKA CPMC
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: deltex 3, E3 ubiquitin ligase; deltex homolog 3; Deltex3; FLJ34766; MGC138863; MGC138864; Probable E3 ubiquitin-protein ligase DTX3; Protein deltex-3; RING finger protein 154; RING-type E3 ubiquitin transferase DTX3
Gene Aliases: deltex3; DTX3; RNF154
UniProt ID: (Human) Q8N9I9
Entrez Gene ID: (Human) 196403
Molecular Function: ubiquitin-protein ligase