Predicted to react with mouse based on sequence homology.
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
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Protein Aliases: 632-; deltex 4 homolog; deltex 4, E3 ubiquitin ligase; deltex homolog 4; Deltex4; DTX4; E3 ubiquitin-protein ligase DTX4; KIAA0937; Protein deltex-4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4; RNF155
Gene Aliases: DTX4; KIAA0937; RNF155
UniProt ID: (Human) Q9Y2E6
Entrez Gene ID: (Human) 23220
Molecular Function: ubiquitin-protein ligase