Immunogen sequence: DSTGTIRGPL KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL AIAQSRVLIA SGVPTVPVKN LNGSSP
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: deltex 4 homolog; deltex 4, E3 ubiquitin ligase; deltex homolog 4; Deltex4; E3 ubiquitin-protein ligase DTX4; Protein deltex-4; RING finger protein 155; RING-type E3 ubiquitin transferase DTX4
Gene Aliases: AI449438; BC044798; D930042H13; DTX4; KIAA0937; RNF155
Molecular Function: ubiquitin-protein ligase