Immunogen sequence: MAARRGALI VLEGVDRAGK STQSRKLVEA LCAAGHRAEL LRFPERSTEI GKLLSSYLQK KSDVEDHSVH LLFSANRWEQ VPLIKEKLSQ GVTLVVDRYA FSGVAFTGAK ENFSLDWCKQ PDVGLPKPDL VLFLQLQLAD AAKRGAFGHE RYENGAFQER ALRCFHQLMK DTTLNWKMVD ASKSIEAVHE DIRVLSEDAI RTATEKPLGE LWK (1-212 aa encoded by BC001827)
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
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Protein Aliases: deoxythymidylate kinase (thymidylate kinase); dTMP kinase; Thymidylate kinase
Gene Aliases: AU044245; CDC8; D10Ertd203e; DTYMK; mtmk; PP3731; Tmk; TMPK; TYMK; TYPK
Molecular Function: nucleotide kinase