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Invitrogen
DTYMK Polyclonal Antibody
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Product Details
PA5-60092
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DTYMK. Recombinant protein control fragment (Product #RP-98924).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGALIVLEGV DRAGKSTQSR KLVEALCAAG HRAELLRFPE RSTEIGKLLS SYLQKKSDVE DHSVHLLFSA NRWEQVPLIK EKLSQGVTLV VDRYAFSGVA
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
Target Information
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: deoxythymidylate kinase (thymidylate kinase); dTMP kinase; Thymidylate kinase
Gene Aliases: CDC8; DTYMK; PP3731; TMPK; TYMK
UniProt ID: (Human) P23919
Entrez Gene ID: (Human) 1841
dUDP biosynthetic process
dTDP biosynthetic process
dTTP biosynthetic process
cell cycle
cell proliferation
nucleobase-containing small molecule interconversion
response to estrogen
myoblast differentiation
response to cadmium ion
nucleotide phosphorylation
nucleoside monophosphate phosphorylation
cellular response to growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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