Immunogen sequence: QHKEELTWED FHFMLRDHNS ELRFTQLCVK GVEVPEVIKD LCRRASYISQ DMICPSPRVS ARCSRSDIET ELTPQRLQCP MDTDPPQEIR RRFGKKVTSF QP
Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.
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Protein Aliases: Dual oxidase 1; flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; NADPH thyroid oxidase 1; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Thyroid oxidase 1
Gene Aliases: DUOX; DUOX1; LNOX1; NOXEF1; THOX1
UniProt ID: (Human) Q9NRD9
Entrez Gene ID: (Human) 53905