The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
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Protein Aliases: Dual oxidase 2; dual oxidase-like domains 2; flavoprotein NADPH oxidase; Large NOX 2; Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; nicotinamide adenine dinucleotide phosphate oxidase; p138 thyroid oxidase; Thyroid oxidase 2
Gene Aliases: DUOX2; LNOX2; NOXEF2; P138-TOX; TDH6; THOX2
UniProt ID: (Human) Q9NRD8
Entrez Gene ID: (Human) 50506