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Dihydrouridine synthase catalyzes reduction of the 5,6-double bond of a uridine residue on the displacement loop of tRNA. The resultant modified base, 5,6-dihydrouridine, appears to increase the conformational flexibility and dynamic motion of tRNA (Kato et al., 2005 [PubMed 15994936]).
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Protein Aliases: Dihydrouridine synthase 2; dihydrouridine synthase 2-like, SMM1 homolog; DUS2; hDUS2; SMM1; SMM1 homolog; tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase (NAD(P)(+)); tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; up-regulated in lung cancer 8; Up-regulated in lung cancer protein 8; URLC8
Gene Aliases: 2310016K04Rik; DUS2; DUS2L; SMM1; URLC8