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DUSP14 Antibody (PA5-28094) in WB
Western Blot analysis of DUSP14 was performed by separating 20 µg of whole cell lysates by 12% SDS PAGE. Proteins were transferred to a membrane and probed with a DUSP14 Polyclonal Antibody (Product # PA5-28094) at a dilution of 1:1000. A: 293T cell line non-transfected lysate, B. 293T cell line MKP-6 transfected lysate.
Product Details
PA5-28094
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 136 and 198 of Human MKP-6
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7, with 40% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545570
Product Specific Information
Recommended positive controls: MKP-6 tansfected 293T cell.^M
^M
Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 14; MAP kinase phosphatase 6; Mitogen-activated protein kinase phosphatase 6; MKP-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; MKP-6; MKP-L
Gene Aliases: DUSP14; MKP-L; MKP6
UniProt ID: (Human) O95147
Entrez Gene ID: (Human) 11072
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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