PA5-28007 targets DUSP19 in WB applications and shows reactivity with Human samples.
The PA5-28007 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 217 of Human DUSP19.
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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).
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Protein Aliases: Dual specificity phosphatase TS-DSP1; Dual specificity protein phosphatase 19; DUSP17; LMW-DSP3; LMWDSP3; Low molecular weight dual specificity phosphatase 3; Protein phosphatase SKRP1; SAPK pathway-regulating phosphatase 1; SKRP1; stress-activated protein kinase pathway-regulating ph; Stress-activated protein kinase pathway-regulating phosphatase 1; TS-DSP1
Gene Aliases: DUSP17; DUSP19; LMWDSP3; SKRP1; TS-DSP1
UniProt ID: (Human) Q8WTR2
Entrez Gene ID: (Human) 142679