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Invitrogen
DUSP22 Polyclonal Antibody
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Product Details
PA5-33488
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 20 amino acid peptide from internal region of human DUSP22.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Elephant (100%) Monkey, Marmoset, Horse (95%) Hamster, Dog, Bat, Rabbit (90%).
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586F2224; Dual specificity protein phosphatase 22; dual-specificity phosphatase; epididymis secretory sperm binding protein; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK pathway associated phosphatase; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; Mitogen-activated protein kinase phosphatase x; PYST2; unnamed protein product
Gene Aliases: DUSP22; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
UniProt ID: (Human) Q9NRW4
Entrez Gene ID: (Human) 56940
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
hydrolase activity
protein tyrosine kinase inhibitor activity
protein tyrosine kinase binding
negative regulation of transcription from RNA polymerase II promoter
immune system process
negative regulation of T cell mediated immunity
negative regulation of cell adhesion
signal transduction
transforming growth factor beta receptor signaling pathway
negative regulation of cell migration
intracellular signal transduction
regulation of cell proliferation
positive regulation of JNK cascade
T cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
negative regulation of T cell activation
negative regulation of focal adhesion assembly
protein K63-linked ubiquitination
protein K48-linked ubiquitination
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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